Βeta-Cells: Stress, Identity, Failure and Diabetes - PubMed
6 hours ago
- #metabolic stress
- #Type 2 diabetes
- #β-cell dysfunction
- Type 2 diabetes (T2D) is a global health challenge driven by modern diet and lifestyle.
- Pancreatic β-cell dysfunction is central to T2D progression, disrupting glucose homeostasis.
- β-cells initially compensate for insulin resistance but fail under chronic metabolic stress.
- Key factors in β-cell failure include ER stress, mitochondrial dysfunction, and inflammation.
- Loss of β-cell identity and altered islet microenvironment interactions contribute to dysfunction.
- Understanding these mechanisms is crucial for developing strategies to prevent T2D progression.