Targeting TREM2 to disentangle neuroinflammation and α-Syn pathological propagation in Parkinson's disease - PubMed
5 hours ago
- #TREM2
- #Parkinson's disease
- #Neuroinflammation
- Parkinson's disease (PD) is a neurodegenerative disorder affecting the central nervous system, characterized by dopaminergic neuron loss and α-synuclein (α-Syn) aggregation.
- TREM2, a regulator of microglial function, plays a key role in PD by mediating phagocytosis, inflammation, autophagy, and neuronal repair.
- Recent advances highlight the genetic link between TREM2 variants and PD, and TREM2's role in α-Syn propagation and neuroinflammation.
- The review discusses TREM2's molecular structure, signaling mechanisms, and its impact on α-Syn metabolism, microglial polarization, and neuron survival.
- TREM2 gene variants and their interaction with environmental factors are analyzed for their pathological significance in PD.
- Therapeutic strategies targeting TREM2 signaling in PD are reviewed, alongside current research controversies and future directions.