SUCNR1 coordinates metabolic flux, mitochondrial function, and nutrient-dependent adaptation in hepatocytes - PubMed
5 hours ago
- #Hepatocytes
- #SUCNR1
- #Metabolic Adaptation
- Succinate receptor 1 (SUCNR1) in hepatocytes is crucial for metabolic adaptation and mitochondrial function.
- Mice lacking hepatic Sucnr1 exhibit fasting-like symptoms, including increased gluconeogenesis and impaired metabolic flexibility.
- SUCNR1 loss disrupts glucose oxidative flux and increases reliance on glutamine, leading to mitochondrial stress.
- SUCNR1 expression is nutritionally regulated, enriched in pericentral hepatocytes, and important for metabolic reprogramming without affecting liver zonation.
- Sucnr1 deficiency impairs mTOR activation and glycogen restoration after refeeding, altering hepatic proteomic responses.