BACH2 links β1-adrenergic receptor/β-arrestin1 signaling to MIAT to inhibit cardiac fibroblast activation and cardiomyocyte apoptosis - PubMed
6 hours ago
- #BACH2
- #cardiac remodeling
- #MIAT
- BACH2 links β1-adrenergic receptor/β-arrestin1 signaling to MIAT to inhibit cardiac fibroblast activation and cardiomyocyte apoptosis.
- MIAT, a long noncoding RNA, is upregulated in failing human and murine hearts and its ablation attenuates maladaptive cardiac remodeling.
- β-blocker carvedilol downregulates MIAT via β1-adrenergic receptor/β-arrestin1 signaling and upregulates BACH2.
- BACH2 forms a nuclear complex with β-arrestin1 and binds to the MIAT promoter to repress its expression.
- BACH2-mediated repression of MIAT inhibits cardiac fibroblast activation and cardiomyocyte apoptosis.
- The study identifies a novel regulatory axis involving β1-adrenergic receptor/β-arrestin1 signaling, BACH2, and MIAT in cardiac remodeling.