The longitudinal and reversible causal link between depressive symptoms and cardiovascular disease among middle-aged and older adults: findings from three national cohorts - PubMed
7 hours ago
- #cardiovascular disease
- #depressive symptoms
- #causal inference
- Study explores the longitudinal and reversible causal link between depressive symptoms and cardiovascular disease (CVD) in middle-aged and older adults.
- Analyzed data from 37,668 participants across three national cohorts: CHARLS (China), HRS (USA), and KLoSA (South Korea).
- Used Longitudinal Targeted Maximum Likelihood Estimation (LTMLE) method to assess causal effects over five time points.
- Found that persistent depressive symptoms significantly increase CVD risk over time, with risk increasing with longer follow-up durations.
- Subgroup analyses by gender and age were conducted, along with multiple sensitivity analyses to validate findings.
- Results show a temporal cumulative effect and a reversible association between depressive symptoms and CVD risk.
- Highlights the importance of integrating mental health care into CVD prevention strategies.