Heterogeneity of Obese Asthma: A Hierarchical Cluster Analysis from the Australasian Severe Asthma Network - PubMed
2 hours ago
- #cluster analysis
- #obese asthma
- #clinical outcomes
- The study identified three distinct subtypes of obese asthma (OA) through hierarchical cluster analysis.
- Cluster 1: Younger individuals with mild OA, high skeletal muscle mass.
- Cluster 2: Predominantly male smokers with uncontrolled OA, multimorbidity, and eosinophilic inflammation.
- Cluster 3: Predominantly older female nonsmokers with OA, high visceral fat area, and neutrophilic inflammation.
- Clusters 2 and 3 had higher risks of moderate-to-severe asthma exacerbations and lower likelihood of clinical remission.
- Decision tree analysis validated cluster assignments with 88.93% accuracy in a separate dataset.