Genome-wide analysis of cardiac ventricular phenotypes reveals novel loci and therapeutic targets for heart failure - PubMed
5 hours ago
- #therapeutic targets
- #heart failure
- #genome-wide analysis
- Genome-wide association analyses of 20 left and right cardiovascular magnetic resonance phenotypes in 56,509 UK Biobank participants.
- Identification of 200 loci associated with ventricular phenotypes, including 58 novel loci.
- Polygenic risk score for left ventricular global function index negatively associated with heart failure.
- Rare variant analysis reveals enrichment of deleterious variants across 13 genes.
- Colocalisation with heart failure implicates 23 shared loci, prioritizing genes like HSPB7, CAMK2D, ALDH2, ENG, and YWHAE.
- Druggability analysis highlights PDE3A, suggesting potential therapeutic targets for heart failure.