Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target - PubMed
6 hours ago
- #Epigenetics
- #Ageing
- #Chromatin
- Systemic epigenetic dysregulation is proposed as a key driver of ageing, and a therapeutic target.
- A framework identifies four interdependent processes leading to loss of epigenetic fidelity during ageing: deterioration of nuclear architecture, dysregulation of epigenetic memory via complexes like PRC2, nucleosome alterations involving H3.3 accumulation, and transcription reprogramming.
- These processes interact via cross-regulatory feedback, causing cascading failures in gene expression and cell-state maintenance.
- The interconnected chromatin regulation mechanisms offer concrete therapeutic targets to restore coherence, enabling rational design of ageing interventions targeting epigenetic systems.