Molecular mechanisms of exercise-induced improvements in Alzheimer's disease: a focus on lipid homeostasis - PubMed

6 hours ago

Alzheimer's disease (AD) is the most prevalent type of dementia with complex pathophysiological mechanisms.
Lipid dysregulation in AD patients is linked to disease progression and is a potential target for early diagnosis and intervention.
Pharmacological therapies targeting lipid homeostasis have limited effectiveness and side effects in AD treatment.
Exercise, a holistic intervention, can modulate lipid levels and slow AD progression with minimal side effects.
The review discusses alterations in lipids (fatty acids, triglycerides, etc.) in AD and how exercise influences lipid metabolism.
Lipids may mediate peripheral-central crosstalk between exercise and AD, with apolipoprotein E genotypes affecting exercise response.
The insights provide a basis for nonpharmacological AD interventions and lipid-related therapeutic targets.

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