Long-term systemic effects of metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD/MAFLD) in children: a systematic review of persistence and progression into adulthood - Pu
5 hours ago
- #Pediatric Health
- #Long-Term Outcomes
- #MASLD
- MASLD (formerly NAFLD/MAFLD) is increasingly common in obese children and adolescents.
- Long-term risks include type 2 diabetes, cardiovascular disease, advanced liver conditions, and liver-related mortality.
- Systematic review analyzed 26 longitudinal studies with follow-ups from 4.5 to 39 years.
- Diagnostic methods varied, including imaging, liver biopsy, and biomarkers like ALT, AST, and genetic variants (PNPLA3, TM6SF2).
- MASLD often progresses silently in children with low awareness among parents and healthcare providers.
- Fragmented medical records and low follow-up rates complicate transition from pediatric to adult care.
- Highlights the need for more comprehensive longitudinal research on MASLD progression and systemic effects.
- Emphasizes early identification, timely intervention, and sustained care to mitigate long-term health consequences.