C3 Glomerulopathy Diagnosis, Current Treatments, and Emerging Therapies - PubMed
3 days ago
- #kidney disease
- #C3 glomerulopathy
- #complement inhibitors
- C3 glomerulopathy (C3G) is characterized by C3 deposition in kidney glomeruli, causing inflammation.
- C3G is rare, caused by dysregulation of the alternative complement pathway, and affects both children and adults.
- Diagnosis of C3G is confirmed via kidney biopsy.
- Approximately 50% of C3G cases progress to kidney failure.
- Current treatments include immunosuppression and supportive care, with variable efficacy.
- The review covers pathophysiology, clinical presentations, diagnostic criteria, current treatments, and ongoing clinical trials.