Inner-retinal changes in AMD: Evidence, mechanisms, and future perspectives - PubMed
5 hours ago
- #OCT
- #inner-retina
- #Age-related macular degeneration
- AMD traditionally viewed as outer-retina and choroid disorder, but inner-retina involvement is now evident.
- Advances in OCT and OCTA reveal inner-retinal changes like thinning, vascular rarefaction, and gliosis.
- Inner-retinal changes can occur early in AMD, sometimes before outer-retinal degeneration.
- Bidirectional neurodegeneration model suggests interactions between inner and outer retinal pathology.
- Inner-retinal changes contribute to visual dysfunction beyond photoreceptor loss.
- New insights support AMD as a multi-layer neurovascular disease.
- Potential for earlier diagnosis and new therapies by targeting inner-retinal integrity.