B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes - PubMed
5 hours ago
- #germinal center
- #immune memory
- #B lymphocytes
- B lymphocytes entering the germinal center late preferentially become memory cells recognizing subdominant epitopes.
- A dual-recombinase reporter approach was developed to trace B cell lineages before and after germinal center entry.
- Invader-derived memory B cells (MBCs) had fewer somatic mutations, lower affinity, and targeted subdominant epitopes compared to founder MBCs.
- These late-arriving B cells contribute to immune memory diversification after vaccination or infection.
- The study involved immunization with haptenated antigen, Tenivac vaccine, and SARS-CoV-2, as well as murine-adapted influenza A infection.