Stochastic misfolding drives the emergence of distinct α-synuclein strains - PubMed
5 hours ago
- #synucleinopathies
- #α-synuclein
- #protein aggregation
- Stochastic misfolding leads to distinct α-synuclein strains, explaining clinical and pathological differences in synucleinopathies.
- Conformational heterogeneity observed in α-synuclein pre-formed fibrils (PFFs) and brain-derived aggregates in transgenic mice.
- Propagation of diverse α-synuclein strains in mice initiates multiple distinct synucleinopathies.
- Spontaneous formation of multiple self-propagating α-synuclein strains occurs even in identical environments.
- Highlights the need to consider intrinsic variability in synucleinopathy research tools for experimental design and interpretation.