Efficacy of vitamin D supplementation in patients diagnosed with depression: a dose-response meta-analysis of randomized controlled trials - PubMed
21 hours ago
- #depression
- #meta-analysis
- #vitamin D
- Vitamin D supplementation significantly improves depressive symptoms compared to placebo (SMD: -0.98; 95% CI -1.28 to -0.68; p < 0.001) based on 15 studies with 962 participants.
- Dose-response analysis shows higher daily doses, up to 5,000 IU/day, are associated with the greatest reduction in depressive symptoms.
- Secondary outcomes include significant reductions in serum PTH and TNFα levels in intervention groups, suggesting anti-inflammatory mechanisms, while BMI, weight, and IL-6 showed no significant changes.
- The study concludes vitamin D may be an effective adjunctive therapy for depression, with efficacy linked to dosage within the studied populations.