Vitamin D deficiency in polycystic ovary syndrome: a retrospective study integrating Mendelian randomization - PubMed
11 hours ago
- #PCOS
- #Vitamin D
- #Mendelian Randomization
- Study investigates the link between vitamin D deficiency and polycystic ovary syndrome (PCOS).
- Retrospective analysis with Mendelian randomization (MR) used clinical data from PCOS patients.
- PCOS patients showed higher rates of vitamin D deficiency compared to healthy controls.
- Vitamin D deficiency associated with weight gain, insulin resistance, and chronic inflammation.
- Vitamin D may reduce testosterone levels and influence SHBG synthesis affecting PCOS development.
- MR analysis suggests vitamin D deficiency worsens PCOS through insulin resistance.
- BMI and testosterone levels positively associated with PCOS; SHBG inversely related.
- Nomogram from multivariate modeling showed high predictive accuracy for PCOS.
- Vitamin D deficiency significantly linked to PCOS, potentially exacerbating metabolic dysfunction.
- Further studies needed to assess if vitamin D supplementation improves PCOS outcomes.