Accessory microRNA byproducts expand RNA interference via microprocessor-mediated cleavage activation - PubMed
7 days ago
- #microRNA
- #glioblastoma
- #RNA interference
- A microRNA-based platform exploits previously unrecognized features of microRNA processing for RNA interference.
- The platform uses a microprocessor-dependent, cleave-activation strategy to simultaneously up- and down-regulate desired microRNAs.
- MicroRNAs are used as structural enablers for other short, noncoding RNAs, such as aptamers.
- Demonstrated in a glioblastoma model, the platform achieves critical mass interference against the tumor by modulating five deregulated microRNAs.
- The platform also chaperones an anti-p50 aptamer to block the nuclear factor κB pathway, a difficult-to-drug target.
- Highlights the potential of chimeric microRNA clusters as a therapeutic concept for multifactorial diseases like cancer.
- Authors disclose competing interests, including equity holdings and advisory roles in biotech companies.
- Part of the methodology is covered under US patents.