Anti-Nogo-A NG101 treatment induces changes in spinal cord micro- and macrostructure following spinal cord injury - PubMed
3 hours ago
- #neural repair
- #spinal cord injury
- #MRI biomarkers
- NG101, an antibody neutralizing Nogo-A, promotes neural repair and improves motor function in spinal cord injury (SCI).
- MRI biomarkers (lesion volume, tissue bridges, CSA, MTsat) were used to assess structural changes in 106 acute cervical SCI patients.
- NG101 treatment led to faster lesion reduction and slower decline in cord area and myelin in key tracts compared to placebo.
- Combining MRI with electrophysiology enhanced detection of clinical treatment effects and improved patient stratification.
- NG101 appears to slow progressive degeneration or promote fiber sprouting, supporting its potential in SCI therapy.