An osteoimmunomodulatory microneedle patch targeting ER-mitochondria calcium crosstalk for periodontal tissue regeneration - PubMed
3 days ago
- #calcium homeostasis
- #osteoimmunomodulation
- #periodontal regeneration
- An osteoimmunomodulatory microneedle patch (OIMN) targets ER-mitochondria calcium crosstalk for periodontal tissue regeneration.
- ERS and mitochondrial dysfunction drive macrophage proinflammatory activation, linked by dysregulated intracellular Ca2+ transport.
- Dual-functional polydopamine nanoparticles (PDAB NPs) scavenge excessive Ca2+ and deliver BMP9 for osteogenic activity.
- OIMN integrates decellularized extracellular matrix (dECM) for localized PDAB NPs delivery, overcoming anatomical constraints.
- OIMN restores ERS and mitochondrial homeostasis, remodels macrophage polarization, and mitigates periodontal inflammation.
- Improved osteoimmune microenvironment promotes BMSCs osteogenic differentiation and accelerates periodontal bone regeneration.
- The study offers a novel therapeutic strategy for periodontitis and a paradigm for inflammatory bone diseases.