Molecular mechanism of Alzheimer's disease using integrated multi-omics - PubMed
6 hours ago
- #Alzheimer's disease
- #multi-omics
- #neuroinflammation
- Alzheimer's disease involves neuroinflammation, immune dysregulation, metabolic impairment, and disrupted synaptic plasticity.
- Key contributors include maladaptive microglial activation, chronic cytokine signaling, and HPA-axis hyperactivity.
- Genetic risk genes like APOE, TREM2, and CR1 highlight immune and metabolic pathway involvement.
- Deficits in autophagy exacerbate amyloid-β and tau aggregation, accelerating synaptic loss.
- GWAS findings, neuroimmune crosstalk, chronic stress via HPA dysregulation, and metabolic reprogramming are discussed.