Autophagy-exosome crosstalk in neurodegeneration: Mechanisms and therapeutic opportunities - PubMed
4 hours ago
- #exosomes
- #autophagy
- #neurodegeneration
- Neurodegenerative diseases (NDs) share disrupted proteostasis due to impaired autophagy and maladaptive exosome dynamics.
- Autophagy normally clears misfolded proteins, while exosomes facilitate neuroglial communication.
- Impaired autophagy can redirect undegraded cargo into exosomes, spreading pathogenic proteins like amyloid-β and α-synuclein.
- Dysregulation of autophagy-exosome crosstalk amplifies neuroinflammation, demyelination, and neuronal loss.
- Pharmacological strategies include rapamycin and resveratrol to enhance autophagy, and engineered exosomes for neuroprotection.
- Translational challenges include safety, biodistribution, dosing, and standardization.
- AI and machine learning can aid in early diagnosis, patient stratification, and therapy optimization.
- Deep learning may enable rational drug design for targeted exosome delivery to the brain.
- The autophagy-exosome axis links intracellular clearance with intercellular signaling, offering diagnostic and therapeutic potential for NDs.