Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults - PubMed
7 hours ago
- #HIIT
- #microRNA
- #obesity aging
- The study investigated microRNA changes in muscle and serum after a 12-week HIIT program, with or without L-citrulline supplementation, in obese older adults.
- HIIT did not alter the expression of classic myo-microRNAs (like miR-133a, -1, -206) or muscle-related microRNAs.
- Changes in specific muscle and circulating microRNAs were associated with improvements in body composition, functional capacity, insulin sensitivity, and metabolic markers.
- L-citrulline supplementation combined with HIIT reduced muscle miR-504-5p, correlating with reduced body fat, improved function, muscle power, and increased IGF-1.
- MicroRNA modulations (e.g., miR-744-5p, miR-151a-3p, miR-4433b-5p, miR-106b-5p) showed associations with clinical benefits, suggesting their potential as biomarkers for HIIT response.