DAXX governs the silencing of LINE1 during spermatogenesis in mice - PubMed
5 hours ago
- #epigenetics
- #spermatogenesis
- #LINE1
- DAXX is essential for silencing transposable elements during spermatogenesis in mice.
- Daxx knockout mice showed delayed meiosis, spermiogenesis defects, and declining fertility with age.
- DAXX suppresses young LINE1 and ERV subfamilies by regulating H3K9me3 and DNA methylation.
- The study identifies DAXX as a new regulator of spermatogenesis and epigenetic silencing of LINE1s.