The Role of Inflammatory Biomarkers in Disease Severity and Treatment Response across Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa-A Narrative Review - PubMed
3 hours ago
- #precision medicine
- #inflammatory biomarkers
- #chronic inflammatory skin diseases
- Inflammatory biomarkers provide insights into disease activity, treatment response, and cardiometabolic risk in chronic inflammatory skin diseases (psoriasis, atopic dermatitis, hidradenitis suppurativa).
- Dysregulated Fas/FasL signaling is linked to keratinocyte apoptosis resistance and chronic inflammation in psoriasis and atopic dermatitis.
- Elevated IL-21 correlates with clinical severity and epidermal hyperplasia in psoriasis and atopic dermatitis, but its role in hidradenitis suppurativa is unexplored.
- Hematology-derived indices (e.g., NLR, PLR, SII) show associations with systemic inflammation and cardiometabolic risk, though diagnostic performance varies and standardization is lacking.
- Integrating tissue-specific, circulating, and hematologic biomarkers into multimodal panels may enhance precision monitoring and personalized care, pending validation through prospective multicenter studies.