Impact of physical activity patterns on major adverse cardiovascular events in adults with hypertension - PubMed
5 hours ago
- #Cardiovascular Diseases
- #Physical activity
- #Hypertension
- Physical activity (PA) is generally cardioprotective, but the relationship between PA intensity and bout length and major adverse cardiovascular events (MACEs) in adults with hypertension remains unclear.
- Participants of the UK Biobank wearables substudy with a clinical diagnosis of hypertension were included.
- Short bouts of moderate intensity PA were classified as lasting up to 3 min and for vigorous intensity up to 1 min.
- Long bouts of moderate intensity PA were classified as lasting >5 min and for vigorous intensity >2 min.
- MACEs were defined as the composite of cardiovascular disease mortality and incidence of stroke, myocardial infarction and heart failure.
- During an average follow-up of 7.9 (±1.1) years among 38 960 participants (58.1% female; average age 62.1 (±7.7) years), there were 1416 MACE, including 397 stroke, 508 myocardial infarction and 363 heart failure events.
- Both short and long bouts of moderate intensity PA were associated with lower MACE risk, with subtype analyses showing longer bouts may enhance protective associations.
- For vigorous intensity PA, amounts accrued through short bouts exhibited a consistent association with lower MACE risk (HR=0.62 (95% CI 0.51 to 0.76) for 22 min/week), while amounts accrued through long bouts were associated with a higher risk of stroke, with a steep gradient of higher risk with longer durations (HR=2.06 (95% CI 1.38 to 3.07) for 44 min/week up to 2.80 (95% CI 1.72 to 4.56) for 64 min/week).
- Short and long bouts of moderate intensity PA were associated with a lower risk of overall MACE, with evidence suggesting that longer bouts may enhance this protective association.
- For vigorous intensity PA, short bouts showed strong associations with lower overall MACE risk, while long bouts were associated with a 2-3 fold higher stroke risk, with a dose-response pattern evident across higher durations.
- Our results highlight the benefits and risks of PA bout length and intensity in adults with hypertension.