Inflammaging-Induced Bioenergetic Gap Exhausts Pulmonary Nucleotide Pools to Exacerbate SARS-CoV-2 Outcomes in Early Stage Aging - PubMed
6 hours ago
- #metabolomics
- #SARS-CoV-2
- #inflammaging
- Age is a key risk factor for COVID-19 morbidity.
- Inflammaging predisposes older hosts to severe SARS-CoV-2 outcomes via metabolic shifts.
- 16-week-old mice showed worse weight loss and pulmonary pathology than 8-week-old mice.
- Multiomics revealed a 'systemic bioenergetic gap' with depleted pulmonary nucleotide pools.
- Suppressed TCA cycle metabolites correlated with reduced antiviral effectors.
- Threonic acid, betaine, and d-ribose were identified as age-dependent severity biomarkers.
- The study suggests systemic metabolic resuscitation as a therapeutic target for elderly COVID-19 patients.