Smart control of CAR-T cells: emerging strategies for safer and more effective cancer immunotherapy - PubMed
5 hours ago
- #CAR-T therapy
- #smart control
- #synthetic biology
- CAR-T cell therapy advances cancer immunotherapy but faces challenges like toxicities, antigen escape, and limited solid tumor efficacy.
- Smart control systems aim to improve safety and precision through tunable, reversible, and context-dependent mechanisms.
- Key strategies include inducible CAR expression, logic-gated receptors, and external controls using drugs, light, or biomaterials.
- Synthetic biology integrates sensor circuits and feedback loops for programmable immunity and real-time adjustment of CAR-T activity.
- The study reviews molecular, genetic, and synthetic approaches to regulate CAR-T activation, persistence, and cytotoxicity with high precision.