Biodistribution of AAV-TT and AAV9 in the Nonhuman Primate Brain - PubMed
4 days ago
- #gene therapy
- #neurodegenerative disorders
- #AAV-TT
- AAV-TT is an adeno-associated virus variant with enhanced CNS tropism and efficient retrograde transport in brain circuits.
- AAV-TT and AAV9 were compared in Macaca fascicularis by injecting GFP-expressing vectors into the putamen.
- Both AAV-TT and AAV9 showed similar distribution patterns, but AAV-TT had slightly higher neuronal transduction efficiency.
- The study supports AAV-TT as a promising tool for neurodegenerative disease modeling and therapy targeting distributed neural circuits.