Pseudomonas aeruginosa gene expression changes during established biofilm infection in a cystic fibrosis lung model - PubMed
4 hours ago
- #cystic fibrosis
- #Pseudomonas aeruginosa
- #biofilm
- Pseudomonas aeruginosa forms persistent biofilm infections in cystic fibrosis (CF) lungs.
- The study uses an ex vivo pig lung (EVPL) model to mimic CF lung infection conditions.
- P. aeruginosa biofilm in EVPL shows increased antibiotic tolerance over 7 days.
- Key findings include upregulation of sulphur metabolism and structured biofilm maintenance.
- No significant differential expression of antimicrobial resistance-associated genes was observed.
- The EVPL model is viable for studying chronic biofilm infections at 7 days post-infection.