TNF-α drives pancreatic microcirculatory dysfunction via CD8+ T cell-mediated endothelial injury in severe acute pancreatitis - PubMed
4 hours ago
- #TNF-α
- #severe acute pancreatitis
- #microcirculatory dysfunction
- TNF-α drives microcirculatory dysfunction in severe acute pancreatitis via CD8+ T cell-mediated endothelial injury.
- Single-cell analysis of human SAP tissues reveals the TNF-α/ULBP/NKG2D axis as a key pathogenic immune-endothelial circuit.
- Inhibition of TNF-α or CD8+ T cells in preclinical models preserves microvascular integrity, reduces tissue damage, and improves survival.