Opioid Free anesthesia in cardiac surgery: The OFACAR randomized clinical trial - PubMed
4 hours ago
- #clinical trial
- #opioid-free anesthesia
- #cardiac surgery
- The OFACAR trial investigated opioid-free anesthesia (OFA) versus opioid anesthesia in cardiac surgery.
- OFA involved ketamine, dexamethasone, lidocaine, and magnesium sulfate, while the control used sufentanil.
- Primary outcome was a composite of complications or death within 30 days after surgery.
- OFA reduced the primary outcome (75.4% vs. 84.5%) with a risk ratio of 0.90 and P=0.049.
- OFA significantly lowered cardiovascular and digestive complications, with no deaths compared to 6 in the control group.
- The fragility index of 1 suggests results are hypothesis-generating and require confirmation in larger trials.