Asymptomatic and symptomatic cardiac toxicity associated with immune checkpoint inhibitors: insights from a Japanese registry - PubMed
3 hours ago
- #myocarditis
- #immune checkpoint inhibitors
- #cardiac toxicity
- Study characterized symptomatic vs asymptomatic ICI-associated cardiac toxicity using Japanese registry data.
- Symptomatic patients had higher troponin I and creatine kinase levels and more severe lymphocytic infiltration.
- Asymptomatic cases showed less aggressive inflammation, lower CD8+ infiltration, and limited myocardial damage.
- ICI continuation was more common in asymptomatic group, with only one recurrence; all myocarditis deaths were symptomatic.