Unleashing the potential of bimetallic nanobomb-mediated STING pathway to enhance bispecific T-cell engager against colorectal cancer photo-immunotherapy - PubMed
3 days ago
- #immunotherapy
- #colorectal cancer
- #nanotechnology
- Bispecific T-cell engagers (BiTEs) face challenges like short half-life and on-target off-tumor toxicity.
- A bimetallic-enriched nanobomb (MnO2/Co-DA@BiTE/HPT) was developed to enhance BiTE efficacy by activating innate and adaptive immunity.
- The nanobomb uses Mn2+/Co2+ to activate the STING pathway and photothermal therapy (PTT) to amplify STING signals.
- Hyaluronic acid-modified PD-L1 aptamer (HPT) improves targeting of PD-L1 overexpressing colorectal cancer cells.
- The nanobomb showed efficacy in subcutaneous, metastatic, and postoperative colorectal cancer models.
- The approach improved the immune microenvironment, produced long-term immune memory, and inhibited tumor recurrence and metastasis.