Electric dipole moment drives the dynamics of the TNFR1 complex I signalosome - PubMed
17 hours ago
- #TNFR1
- #Signalosome
- #Electric Dipole Moment
- Electric dipole moment (EDM) drives dynamic assembly and disassembly of complex I signalosome.
- Complex I structure shows a pentameric fiber with TNFR1, TRADD, and RIPK1 death domains.
- Opposing EDMs between RIPK1-DD and TNFR1/TRADD-DD oligomers enable reversibility and NF-κB signaling.