Igniting Endogenous Calcipoptosis via ER-Mitochondrial Calcium Shuttle Hijacking for Potent Antitumor Immunity - PubMed
6 hours ago
- #nanoagonist
- #calcipoptosis
- #calcium immunotherapy
- A modular peptide-programmed nanoagonist was designed to hijack ER-mitochondrial calcium shuttle under ultrasound, inducing endogenous calcipoptosis.
- The nanoagonist causes dual-organelle dysfunction, activating caspase-dependent apoptosis and releasing damage signals to boost dendritic cell maturation and T-cell infiltration.
- Calcium dysregulation also polarizes macrophages to a pro-inflammatory state and stiffens cancer cells, enhancing biochemical and mechanical immunosurveillance.
- This strategy demonstrated potent ablation of primary tumors and suppression of metastasis in breast and liver cancer models without systemic toxicity risks.