Epstein-Barr virus-associated lymphoma: current understanding and treatment strategies - PubMed
4 days ago
- #Epstein-Barr virus
- #Lymphoma
- #Carcinogenesis
- Epstein-Barr virus (EBV) infection has a high prevalence and is linked to various diseases, including cancers and autoimmune conditions.
- Primary EBV infections in young individuals are often asymptomatic, but symptomatic infections like infectious mononucleosis can occur in adolescents and young adults.
- EBV can establish latent infections in B cells, leading to long-term infection and potential carcinogenesis through viral protein expression.
- Latent EBV proteins contribute to cell transformation, immune evasion, angiogenesis, and other processes that drive lymphomagenesis.
- EBV-associated lymphomas include diffuse large B-cell lymphoma, Hodgkin lymphoma, NK/T cell lymphoma, Burkitt lymphoma, post-transplant lymphoproliferative disorders, and primary CNS lymphoma.
- EBV-positive lymphomas generally have a poorer prognosis compared to EBV-negative cases.
- This review explores the pathogenesis of EBV-associated lymphomas and evaluates current and emerging treatment strategies.