Lipoprotein(a), High-Sensitivity C-Reactive Protein, and Incident ASCVD Risk in Individuals Without Standard Modifiable Risk Factors - PubMed
5 hours ago
- #ASCVD risk
- #SMuRF-less individuals
- #biomarkers
- Lipoprotein(a) (Lp(a)) and high-sensitivity C-reactive protein (hsCRP) were studied for predicting incident atherosclerotic cardiovascular disease (ASCVD) in individuals without standard modifiable risk factors (SMuRFs).
- The research included 50,450 UK Biobank participants free of cardiovascular disease and SMuRFs, with 1,104 ASCVD events over 15 years of follow-up.
- Elevated hsCRP was associated with a higher ASCVD risk (subdistribution hazard ratio 1.35), while elevated Lp(a) showed a more modest association (subdistribution hazard ratio 1.24).
- Individuals with concurrent elevations of both markers had the highest ASCVD risk (subdistribution hazard ratio 1.64 with cohort-specific cutoffs and 1.74 with clinical cutoffs), without evidence of interaction.
- The findings suggest that combined assessment of Lp(a) and hsCRP can provide complementary information for risk characterization in SMuRF-less adults in primary prevention.