Oncogenic LPP facilitates focal adhesion maturation in response to mechanical tension and regulates the Hippo signaling - PubMed
6 hours ago
- #Oncogenic LPP
- #Focal Adhesion Maturation
- #Hippo Signaling
- LIM family proteins are crucial in mechano-transduction, often dysregulated in cancers.
- Lipoma Preferred Partner (LPP) is amplified and upregulated in various human cancers, linked to poor prognosis.
- LPP is essential for tumor growth and metastasis in multiple tumor models.
- Mechanical stimulation recruits LPP to focal adhesions via VASP, promoting Paxillin-dependent maturation.
- LPP inactivates Hippo pathway kinases LATS1/2 through PP2A-mediated dephosphorylation, activating YAP.
- These findings explain LPP-mediated mechano-transduction and its role in driving tumor progression.