Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization - PubMed
2 days ago
- #Microtubule-binding
- #Colonization
- #Bordetella
- Bordetella bacteria use the FhaB adhesin to infect respiratory epithelia.
- The C-terminal microtubule-binding domain (FhaB-CT) of FhaB is translocated into host cells to aid colonization.
- FhaB-CT delivery is essential for occupying a niche at the base of cilia in airway epithelia.
- Mutant bacteria lacking FhaB-CT are defective in nasal colonization.
- Bordetella initially adheres to cilia tips, then migrates to the base using FhaB adhesins.
- This migration helps bacteria resist clearance by the mucociliary escalator.