Xiayuxue decoction alleviates MASH by regulating gut microbiota, bile acid metabolism, and m6A modification - PubMed
4 days ago
- #metabolism
- #liver disease
- #herbal medicine
- Xiayuxue decoction (XYXD) is a herbal formula used to treat metabolic dysfunction-associated steatohepatitis (MASH).
- XYXD alleviates MASH by regulating gut microbiota, bile acid metabolism, and m6A modification.
- The study used a methionine-choline-deficient (MCD) diet to induce MASH in a model and evaluated XYXD's effects.
- XYXD reverses microbiota imbalance and maintains bile acid homeostasis via the FXR-SHP pathway.
- It reduces Clostridium abundance and deoxycholic acid (DCA) levels, which influence m6A modification and arachidonic acid metabolism.
- XYXD's therapeutic mechanism involves gut microbiota modulation, bile acid regulation, and epigenetic modifications.
- The study highlights XYXD's potential as a systemic treatment for MASH through multi-pathway regulation.