The microbiome and PTSD: a scoping review across preclinical and clinical studies - PubMed
4 days ago
- #microbiome
- #PTSD
- #gut-brain-axis
- PTSD is linked to microbiome alterations and immune changes.
- Human studies show reduced microbial diversity and loss of SCFA-producing bacteria.
- Increased pro-inflammatory species and gut permeability observed in PTSD patients.
- Microbiome-targeted interventions (probiotics, prebiotics, fermented soy) show preliminary benefits.
- Preclinical models reveal stress-induced microbiome changes and functional consequences like impaired barrier integrity.
- Interventions like Mycobacterium vaccae, probiotics, and synbiotics mitigate microbial alterations and anxiety-like behaviors.
- Current research is limited by small, cross-sectional human studies; more rigorous longitudinal and interventional studies needed.