Detecting healthcare-associated transmission and antifungal resistance in Candida auris via whole genome sequencing - PubMed
8 hours ago
- #whole genome sequencing
- #antifungal resistance
- #Candida auris
- Candida auris is an emerging, multidrug-resistant pathogen causing invasive infections and healthcare-associated outbreaks.
- Whole genome sequencing (WGS) with SNP analysis helps detect transmission clusters and predict antifungal resistance.
- Study defined SNP thresholds for outbreak investigations: intra-patient variation up to 14 SNPs, transmission clusters had a median of 5 SNP differences.
- WGS identified genotypic markers for resistance to fluconazole, micafungin, and potential flucytosine resistance.
- Findings support WGS utility for infection prevention and guiding surveillance strategies in healthcare settings.