Hypoxia-inducible protein 2 mediates metabolic adaptation of Ly6ChighLy6Glow monocytes after stroke - PubMed
6 hours ago
- #immunometabolism
- #stroke
- #neuroinflammation
- Ly6Chigh monocytes play a critical role in secondary neuroinflammation after stroke.
- Hypoxia-inducible protein 2 (HIG2) mediates metabolic adaptation in Ly6ChighLy6Glow monocytes.
- HIG2 promotes phosphatidylcholine synthesis via Hif1α-dependent regulation of choline kinase α.
- HIG2 initiates lipid metabolism reprogramming, leading to an anti-inflammatory phenotype in monocytes.
- Intranasal delivery of recombinant HIG2 protein improves neurological outcomes post-stroke.
- Targeting HIG2 could be a novel immunometabolic strategy to reduce neuroinflammation after stroke.