Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation - PubMed
5 hours ago
- #cell death
- #phospholipid peroxidation
- #ferroptosis
- Ferroptosis is a regulated cell death mechanism driven by iron-dependent peroxidation of polyunsaturated phospholipids.
- Susceptibility to ferroptosis is influenced by lipid metabolic pathways, which determine the abundance and redox reactivity of polyunsaturated phospholipids.
- Enzymes incorporating polyunsaturated fatty acids into phospholipids generate substrates for peroxidation, sensitizing cells to ferroptosis.
- Synthesis of monounsaturated phospholipids and lipid-soluble antioxidants protect cells from ferroptosis by limiting phospholipid peroxide accumulation.
- Different tissues exhibit unique ferroptotic responses due to variations in lipid composition and antioxidant capacity.
- Modulating cellular sensitivity to ferroptosis holds potential for treating human diseases.