An Overview of Anticoagulant Drugs Pharmacology, Therapeutic Approaches, Limitations and Perspectives - PubMed
5 hours ago
- #anticoagulants
- #pharmacology
- #thrombosis
- Coagulation is essential for homeostasis but can be pathologically activated, increasing thrombosis risk.
- Traditional anticoagulants (e.g., heparin, vitamin K antagonists) are effective but have limitations like bleeding risks and administration challenges.
- New oral anticoagulants (e.g., dabigatran, rivaroxaban) improve adherence with fewer bleeding risks and no need for lab monitoring.
- Specialized anticoagulants (e.g., argatroban) are available for patients with heparin-induced thrombocytopenia.
- Reversal agents for new anticoagulants have been developed for emergencies like overdoses or surgeries.
- This review highlights the pharmacology, therapeutic uses, and limitations of anticoagulant drugs.