Copper deprivation reprograms antioxidant defense to suppress ferroptosis via SLC7A11 - PubMed
5 hours ago
- #Antioxidant Defense
- #Copper
- #Ferroptosis
- Copper deprivation upregulates SLC7A11, enhancing glutathione synthesis and antioxidant defenses.
- Mechanism involves AMPK activation and NRF2 stabilization to drive SLC7A11 expression.
- Copper loss protects cells from ferroptosis, impacting cancer and tissue injury models.
- Dietary or pharmacological copper modulation could fine-tune ferroptosis in disease contexts.