The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding - PubMed
4 days ago
- #accessory adapters
- #p97-mediated unfolding
- #proteasomal degradation
- Accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by enhancing p97-mediated substrate unfolding.
- These adapters likely position Ufd1 for efficient substrate loading onto p97, boosting unfolding rates.
- A helix-UBX segment in FAF1/2 tethers the UT3 ubiquitin binding module of Ufd1 to the p97 N-domain.
- Mutations disrupting the helix-Ufd1 interaction reduce degradation stimulation, indicating the importance of adapter positioning.
- The study defines the role of accessory adapters in mammals and highlights the complexity of p97 substrate processing.