The role of systemic inflammation in hepatic encephalopathy: advances in inflammatory mechanisms, prevention and treatment research - PubMed
5 hours ago
- #hepatic encephalopathy
- #gut-liver-brain axis
- #systemic inflammation
- Systemic inflammation is a key synergistic driver in hepatic encephalopathy (HE), amplifying ammonia neurotoxicity.
- Gut-liver-brain axis dysfunction, including gut dysbiosis and cirrhosis-associated immune dysfunction, links inflammation to neuroinflammation and cognitive impairment.
- Inflammatory markers like IL-6 correlate with HE severity, highlighting the role of inflammation in disease progression.
- Therapies targeting inflammation, such as rifaximin and fecal microbiota transplantation (FMT), reduce HE recurrence and improve cognitive outcomes.
- Combining anti-inflammatory strategies with traditional ammonia-lowering therapies offers a more effective treatment paradigm for HE.