Restoring neuroplasticity after CNS trauma: cell therapy approaches in spinal cord and traumatic brain injury - PubMed
5 hours ago
- #cell therapy
- #neuroplasticity
- #CNS trauma
- Cell-based therapies are promising for restoring neuroplasticity after spinal cord injury (SCI) and traumatic brain injury (TBI).
- Therapies include bone marrow-derived mesenchymal stem cells (BMSCs), adipose-derived stem cells (ASCs), umbilical cord mesenchymal stem cells (UCMSCs), neural progenitor cells (NPCs), and olfactory ensheathing cells (OECs).
- Clinical studies in SCI report functional improvements with BMSCs and peripheral blood-derived stem cells, but methodological heterogeneity limits conclusions.
- In TBI, preclinical studies show neuroprotective and regenerative potential of mesenchymal stem cell-based therapies, though clinical evidence is limited.
- Cell-free approaches, such as secretome and extracellular vesicle-based strategies, offer benefits while addressing safety and logistical constraints.
- Successful clinical translation requires larger, well-controlled trials and standardized protocols for timing, dosage, and administration routes.