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Senescent-Like Myofibers Contribute to Anti-Regenerative Cytokine Signaling in Duchenne Muscular Dystrophy - PubMed

4 hours ago
  • #Duchenne muscular dystrophy
  • #muscle regeneration
  • #cellular senescence
  • Duchenne muscular dystrophy (DMD) is a genetic disease causing progressive muscle degeneration.
  • p16 expression in skeletal muscles induces cellular senescence in DMD rats, while its ablation enhances muscle regeneration.
  • RNA-seq analysis showed p16-dependent upregulation of cytokine genes in DMD rat muscles, altering systemic blood cytokine profiles.
  • Transplanted muscle regeneration was suppressed in DMD rats but improved with p16 ablation.
  • p16 was found in myofibers of DMD rats, which exhibited p16-dependent cytokine expression.
  • Cytokines from senescent-like myofibers create an anti-regenerative niche in DMD, revealing new disease progression mechanisms and therapeutic targets.